The Mediterranean Diet: Wine

By now we all should know that the Mediterranean diet is a healthy diet. All sorts of positive effects are ascribed to it. The diet consists of olive oil, fresh vegetables, beans, nuts and fresh fish. Only modest amounts of meat and carbohydrates are included in the diet.
I myself think that the easier way of life, a sedentary lifestyle also contributes to a physical and mental health. Less chronic stress, means less stress hormones raging through your body. That chronic stress induces low-level inflammation in your body and your brain.

We already know that several fytochemicals in olives and olive oil (Oleocanthal and Oleuropein) can lower this low-level inflammation, leading to less damage to heart and brain[1][2].

New research found that two phytochemicals, dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc), are effective in promoting resilience against stress by modulating brain synaptic plasticity and peripheral inflammation. DHCA/Mal-gluc also significantly reduces depression-like phenotypes in a mouse model of increased systemic inflammation induced by transplantation of hematopoietic progenitor cells from stress-susceptible mice. DHCA reduces pro-inflammatory interleukin 6 (IL-6) generations by inhibiting DNA methylation at the CpG-rich IL-6 sequences introns 1 and 3, while Mal-gluc modulates synaptic plasticity by increasing histone acetylation of the regulatory sequences of the Rac1 gene. Peripheral inflammation and synaptic maladaptation are in line with newly hypothesized clinical intervention targets for depression that are not addressed by currently available antidepressants.

Sounds interesting? No, the text above is simply the scientific jargon. What it says in normal language is that phytochemicals in grape juice (or wine) may reduce low-level inflammation that is the result of too much stress[3]. It also improves the transmission of signals in the brain.

While the study was done on stressed mice, 70 percent of them demonstrated improved social interactions, which suggests resilience.

Drinking wine and staying healthy was already called the 'French Paradox'. Should I advise you to drink wine or have you reached that conclusion yourself?

[1] Mete et al: Neuroprotective Effects of Oleocanthal, A Compound in Virgin Olive Oil, in A Rat Model of Traumatic Brain Injury in Turkish Neurosurgery – 2017
[2] Casamenti, Stefani: Olive polyphenols: new promising agents to combat aging-associated neurodegeneration in Expert Review in Neurotherapeutics – 2017
[3] Wang et al: Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice in Nature Communications – 2018

No comments:

Post a Comment